New research shows that cigarettes kill 2 out of 3 of its users, more than previously thought. Study looked at 205,000 people over 45 years

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The investigators found the percentage of smokers was comparable among men and women. They also found that current smokers were likely to be younger than never smokers, and they were less likely to live in urban areas. Current smokers had lower income and education when compared to never smokers, and they were less likely to hold private health insurance. Finally, current smokers were more likely to report consuming over 15 alcoholic drinks a week and were more likely to have a higher body mass index.
(These factors were accounted for when the mortality statistics were examined.)
Person-years are a measure of time used in epidemiological studies, in which the years studied for all participants in a study are added together. For example, if three people were studied for 10 years each, 30 total person years would be reported in the study. In the study published in BMC Medicine, a total of 874,120 person-years were examined, and during those person-years, 5,593 deaths occurred among the study population.
Epidemiological outcomes are typically reported in terms of “Relative Risk”, which describes the proportion of the risk of an outcome that can be attributed to a specific factor. In this study, the relative risk of death (known as mortality) for male and female smokers showed that they were approximately 2.76 and 2.95 times more likely to die than never smokers. Quitting helps; male and female past smokers were 1.27 and 1.39 times more likely to die than never smokers. These numbers, while not surprising given the large body of data on the risks of smoking, are nonetheless a staggering reminder of the quantifiable risks of smoking.
The investigators also examined the mortality rate in relation to the number of cigarettes smoked per day. They found that there was a two-fold increase in mortality for participants who smoked 1-14 cigarettes per day and a four-fold increase in mortality for those who smoked more than 25 cigarettes per day (compared to never smokers).
This study does report the promising finding that quitting smoking, even later in life, can considerably reduce the risk of mortality associated with smoking, a finding that’s been demonstrated several times in the literature on smoking. The researchers found that when they compared participants who had quit smoking at ages 45-54, the relative risk of dying for men and women was only 1.36 or 1.52 times the risk of dying in never smokers. They found that the risk of death declined progressively, and this was proportional to the amount of time that passed since the participant quit smoking.

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